![]() ![]() ![]() 7, 8Beta-thalassemia syndromes describe a group of genetic blood disorders caused by decreased or absent synthesis of the β-globin chain, resulting in reduced amount of hemoglobin in RBC, low RBC production and anemia. It has been debated as to whether β-thalassemia minor has increased iron absorption. 5, 6 Thalassemia minor is a carrier state in which only one allele is mutated which can manifest in subsequent generation on marrying a partner of thalassemia minor or major. 4 Iron overload is a common problem with frequent blood transfusions in thalassemia major and inter media (TI). 2, 3Thalassemia has spectrum of manifestations, ranging from asymptomatic nature to severe disease requiring frequent packed red blood cell (RBC) transfusions. 1Beta-thalassemia comprises of a heterogenous group of hemoglobin disorders characterized by reduction or complete absence of -globingene expressionand is inherited as an autosomal recessive disease. These are considered as the world’s most widespread genetic diseases. ![]() The thalassemia syndromes are inherited disorders of globin synthesis.
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